•Meprin
is involved
in cytokine activation and procollagen/collagen cleavage and meprin
β
is highly expressed in kidney epithelial cells
•Relocalization
of meprin
β
after toxic trigger brings the enzyme in contact with a
number of
substrates
•Meprin
KO mice are less susceptible to AKI and meprin
inhibitors were
able
to reduce kidney injury in vivo to some extent.
•MWT-270
is selective meprin
β
inhibitor and showed efficacy in an AKI animal model
