•Identification
and test for tissue and cancer-type specific PIWI-interacting RNAs (piRNAs)
•Anti-cancer
effects of down-regulated piR-37213-L01 both in vitro (cell proliferation, and
colony formation) (Figure 1) and in-vivo (xenograft mouse models in Figure 2
•The
anti-cancer effect of piR-37213-L01 was highly specific for liver cancer
•piR-37213-L01
works in PDX mouse models and uncovering the mechanism of action is under way