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Inflammasome Agonist Proteins for Vaccine and Immunotherapy
Weill Cornell Medicine
Protein
Immunology, Oncology
Target Identification or Validation
• The Technology: Use of bacterial needle and rod proteins as adjuvants to activate the innate immune inflammasome pathway
• The Discovery: Bacterial needle proteins such as PrgI and CprI activate the inflammasome, a signaling complex that produces pro-inflammatory cytokines and mediates adaptive immunity
• PoC Data: Expression of Needle proteins activated the inflammasome and initiated an inflammatory form of cell death called pyroptosis in tumor cells
• Chimeric antibodies consisting of a single-chain variable fragment fused to a Needle protein, tumor antigen, and/or Flagellin activated the inflammasome and caused human dendritic cell maturation, proinflammatory cytokine production,
and tumor antigen MHC-I presentation to T cells
• Expression of Needle proteins in established melanoma tumors in mice led to significant reduction of tumor volume and resolution over time
Julie Magarian Blander
PCT-US2022-012167 (2022.01.12)
Patent Family: PCT
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