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PI5P4 kinase Inhibitors_Neurodegenerative disease
Alborada Drug Discovery Institute
Small molecule
Neurology, CNS disease
Hit To Lead or Lead Optimization
PI(3)P, the product of VPS34, regulates canonical autophagy; however, mammalian cells can produce autophagosomes through enigmatic noncanonical VPS34-independent pathways. Vicinanza et al. show that PI(5)P can regulate autophagy, even in cells where VPS34 is compromised and acts via PI(3)P effectors. This provides a mechanistic explanation for forms of noncanonical autophagy.