88
Nuclear Import (KPNB1)_Cancer
CD3
Small molecule
Oncology
Hit To Lead or Lead Optimization
Elevated expression of diverse importins and exportins (KPNA2, KPNB1, XPO1, XPO2) has been documented in many different cancer cells. Further, down-regulation of KPNA2, KPNB1 and XPO1 inhibited cancer cell proliferation. The inhibitors in development can selectively inhibit KPNA2/7 to restrict nuclear transport of cMYC and other oncogenic factors essential for robust activation of cancer cell survival signaling pathway
