76
BH4_Cancer, Autoimmune diseases
Lead Discovery Center
Small molecule
Immunology, Oncology
Hit To Lead or Lead Optimization
Tetrahydrobiopterin (BH4) is an enzyme cofactor for various aromatic amino acid hydroxylases and it is involved in production of various neurotransmitters and nitric oxide. BH4 is biosynthesized through multiple steps and sepiapterin reductase is critical for the final biosynthesis step of BH4. Inhibition of BH4 biosynthesis via sepiapterin reductase inhibition prevents T cell proliferation and T cell-induced autoimmunity.
US 9963462 B2