73
GLUT 1, 3_Cancer, Autoimmune disorder
Lead Discovery Center
Small molecule
Immunology
Hit To Lead or Lead Optimization
Inhibition of glucose transporters (such as GLUT1 and GLUT3) can increase proliferation of effector T cells while immunosuppressive regulatory T cells are not affected. Simultaneous inhibition of more than one glucose transporter target is critical for achieving adequate immunoregulatory function by inhibitors as GLUTX response regulation makes single-target inhibitor insufficient. Inhibition of glucose transporter can lead to starvation and eventual cancer cell death.