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Periodontitis_Infection
Fraunhofer IZI
Small molecule
Infectious disease
Target Identification or Validation
Periodontitis is one of the most abundant and neglected infectious diseases worldwide. Current Periodontitis drug market valued 347 million USD per year (CAGR 10.2 – 9.2 %). Gingipains are trypsin-like cysteine proteinases produced by Porphyromonas gingivalis, a major causative bacterium of adult periodontitis. It is suggested that gingipain inhibition by gingipain-specific inhibitors is a useful therapy for adult periodontitis caused by P. gingivalis infection.
PCT-EP2017-081190