•cGAS-STING
is a cytosolic DNA sensor pathway which activates innate immune response
•Gain-Of-Function
mutations cause rare type I IFN auto-immune disorders.
•Hyper-activation
of cGAS-STING
in more common type I interferonopathies
(Lupus, RA, …)
•Emerging
role in age-related disorders associated with chronic sensing of cytosolic DNA
(myocardial infarction, lung inflammation, neurodegeneration/neuroinflammation,
and tumorigenesis/metastasis)
•STING
& cGAS
HTS performed & hit selection ongoing
