Asset

  • No.

    61

  • Asset Title

    LEDGF PWWP chromatin tethering_Cancer

  • Organization

    CD3

  • Product Type

    Small molecule

  • Therapeutic Area

    Oncology

  • Development Stage

    Hit To Lead or Lead Optimization

  • Technical Summary

    LEDGF/p75 is a transcriptional co-activator involved in stress response and critical for the clonal expansion. As full structural characterization is available for LEDGF/P75, inhibition of LEDGF-MLL interaction or PWWP chromatin binding may inhibit oncogenic activity of MLL.

  • Researcher

  • Patent

  • Publication

  • Attachment

    CD3_Overview_LEDGF PWWP chromatin tethering_Cancer.pdf
    CD3_Slide deck_iKAP-LEDGF-Hippo-STING..pdf

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