59
OXPHOS, DHODH inhibitor_AML
CD3
Small molecule
Oncology
Hit To Lead or Lead Optimization
Many glycolysis-independent cancer cells require OXPHOS metabolic pathway for survival and are hypersensitive to inhibition of said pathway. OXPHOS mitochondrial metabolism also contributes to an immunosuppression in tumor microenvironment, whereas cytotoxic T cells are dependent on glycolysis, thus suggesting selective targeting of OXPHOS will be beneficial in cancer immunotherapy.