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eIF2B inhibition prevents neurodegeneration
Alborada Drug Discovery Institute
Small molecule
Neurology, CNS disease
Hit To Lead or Lead Optimization
• The researchers developed a chemical inhibitor of the ISR, ISRIB,
reverses the attenuation of eIF2B by phosphorylated eIF2α, protecting mice from neurodegeneration and traumatic brain injury. ISRIB is not toxic to the pancreas and significantly extends survival in animal experiments
• ISRIB is not toxic to the pancreas and significantly extends survival in animal experiments