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Oncolytic virus_Brain Cancer
Yale University
Gene therapy
Oncology
Hit To Lead or Lead Optimization
Lassa-VSV is a novel recombinant oncolytic virus (OV) that can cross the blood brain barrier (BBB) and selectively kill glioma in the brain without the adverse effects of neurotoxicity that is associated with other VSV-related OVs. Lassa-VSV is chimeric VSV where endogenous G protein is replaced with glycoprotein of Lassa.
US 10179154 B2