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Novel Cyclic Dinucleotide Analogues as STING Agonists
University of California, San Diego
Small molecule
Oncology
Hit To Lead or Lead Optimization
Researchers at UC San Diego have developed novel series of c-diGMP analogues that were able to activate the innate immune response through the STING pathway in mammalian cells. Unlike Aduro’s ADU-S100 where phosphate group is modified into S analogue, these analogues incorporate novel nitrogenous bases with regular phosphates.