•Developed
compounds
inhibiting
the activity of HIF-1
•The
HIF-1 inhibitor compounds are designed around the scaffold of naturally
occurring metabolite eudistidine
•Compounds
eudistidine
A (IC50
75uM) and C have been shown to disrupt the HIF-1/p300 interaction in vitro. Eudistidine
C has also inhibited growth of malaria at low micromolar
concentrations