•RNA
interference (RNAi) is a biological response to double-stranded RNA that
regulates expression of protein-coding genes and is a natural mechanism for
gene silencing. Delivery of short, interfering RNA (siRNA) leads to RNAi of the
targeted genes
•A
tetrahedral-shaped RNA nanoparticle comprised of four RNA nanorings
for the delivery of siRNA to activate RNAi
•Containing
up to twelve Dicer substrate RNA duplexes, enabling the simultaneous targeting
of multiple genes with several siRNA copies