•Synthetic
IL-15 and IL-21 molecules for autocrine expression by the engineered
therapeutic T cells developed
•These
molecules were designed with flexible linkers that connect to cell membrane
anchors. This, in turn, reduces systemic toxicity caused by free cytokine
molecules
•Shown
that co-expression of the novel IL-15 and IL-21 tethered molecules improves the
anti-tumor efficacy of the therapeutic engineered T cells in vivo