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Inhibin analogues for post-menopausal osteoporosis treatment
Monash University
Protein
Obstetrics / Gynecology
Hit To Lead or Lead Optimization
We have developed super-inhibin analogues that can be used to prevent osteoporosis and weight gain during menopause, and beyond. The potential for inhibin therapeutics has been challenged by the concomitant production of activins, which induces cachexia in inhibin-null mice. We have identified mutations that eliminate activin formation in the production of potent inhibin analogues that can be used develop a first inhibin replacement therapy.