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Nuak1 inhibitor_Neurodegenerative disease
Alborada Drug Discovery Institute
Small molecule
Neurology, CNS disease
Hit To Lead or Lead Optimization
• The researchers identified Nuak1, an AMPK-related kinase, as directly regulating tau at serine 356. Decreasing Nuak1 reduced tau levels and suppressed phenotypes and neurodegeneration in tau expressing Drosophila and a tauopathy mouse model
• A Nuak1 inhibitor could be a first in class drug for neurodegenerative disorder treatment