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Macrophage Programming for Immunotherapy
University of California, San Diego
Cell therapy
Oncology
Hit To Lead or Lead Optimization
UC San Diego researchers have developed methods and processes for engineering macrophages to carry both response elements and effector modules that can provide directed immunotherapy. By modulating the cellular response profile, macrophages can now target cells that would otherwise evade detection and clearance. By relying on the natural phagocytic process, the therapeutic potential of this technology is enhanced and the off-target risks may be minimized.
PCT-US2018-041766