•AHR
has an important role in hematopoiesis and lymphocyte development
•AHR
is preferentially expressed by myeloma tumor cells and expression level
correlates with overall survival
•AHR
antagonism with off-patent tool inhibitor induces direct cell death of myeloma
stem cells and tumor cells and favorable immunomodulatory effects (expansion,
enhanced activation, and increased cytotoxicity of immune effector cells &
increased susceptibility of myeloma cells to immune mediated recognition and
lysis) (2014)
•Now
designing novel candidate AHR inhibitors and further developing assays to
interrogate their biology