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NLRC5 as a target to intervene MHC class 1 mediated immune responses
Dana Farber
Gene therapy
Oncology
Hit To Lead or Lead Optimization
A method to modulate MHC class I gene expression by modulating NLRC5 expression and/or NLRC5 activity in a subject is provided. The method comprises administering to the subject a compound that modulates NLRC5 expression and/or NLRC5 activity in an amount effective to modulate MHC class I gene expression. Also described is a screen for compounds that modulate NLRC5 expression. Candidate compounds are tested for their ability to modulate NLRC5 expression.
