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Method to Inhibit Neutrophil Recruitment to Damaged Tissue Using Myeloid-Derived Growth Factor
Wisconsin Alumni Research Foundation
Protein
Inflammatory disease
Hit To Lead or Lead Optimization
• Myeloid-derived growth factor (MYDGF) is a damage signal that regulates neutrophil interstitial motility and inflammation through a HIF1a pathway in response to tissue damage.
• Myeloid-derived growth factor (MYDGF) is known to mediate cardiac repair following myocardial infarction by inhibiting cardiac myocyte apoptosis. MYDGF (C19orf10) mediates cardiac repair following myocardial infarction. MYDGF-deficient mice developed larger infarct scars and more severe contractile dysfunction compared to wild-type mice. Treating the mice with recombinant MYDGF reduced scar size and contractile dysfunction after myocardial infarction.
• A method to inhibit neutrophil recruitment to damaged tissue in a subject , the method comprising administering to a subject, the subject having a wound and/or a burn at a site on the subject, an amount of a MYDGF, a biologically active fragment thereof, an analogous sequence thereof , or a pharmaceutically suitable salt of any of the foregoing, wherein the amount is effective to inhibit neutrophil recruitment to the wound and/or burn site.
• A method to inhibit inflammation in a subject, the method comprising administering to the subject an anti-inflammatoryeffective amount of a MYDGF, a biologically active fragment thereof , an analogous sequence thereof, or a pharmaceutically suitable salt of any of the foregoing.
US20220168390A1
Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. J Cell Biol, (2021)
