Asset

  • No.

    119

  • Asset Title

    CSF1-Receptor Inhibitors

  • Organization

    Lead Discovery Center

  • Product Type

    Small molecule

  • Therapeutic Area

    Inflammatory disease

  • Development Stage

    Hit To Lead or Lead Optimization

  • Technical Summary

    • As a potential target for many indications, CSF1R inhibition results in a reduction of the CSF1R dependent kinase phosphorylation, proliferation, and pro-inflammatory cytokine production, e.g., in primary murine microglia 

    • During inflammation, the CSF1-Receptor is upregulated in several preclinical murine models of neuroinflammation and neurodegeneration - NTNU & LDC primarily focus on (neuro)inflammation.

    • Inflammation is a common neuropathological feature in several neurological disorders (e.g., ALS, TBI). 

    • Objective: Generation of BBB permeable, potent, effective and selective CSF1R inhibitors to prevent neuroinflammation  

  • Patent

  • Publication

  • Attachment

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