119
CSF1-Receptor Inhibitors
Lead Discovery Center
Small molecule
Inflammatory disease
Hit To Lead or Lead Optimization
• As a potential target for many indications, CSF1R inhibition results in a reduction of the CSF1R dependent kinase phosphorylation, proliferation, and pro-inflammatory cytokine production, e.g., in primary murine microglia
• During inflammation, the CSF1-Receptor is upregulated in several preclinical murine models of neuroinflammation and neurodegeneration - NTNU & LDC primarily focus on (neuro)inflammation.
• Inflammation is a common neuropathological feature in several neurological disorders (e.g., ALS, TBI).
• Objective: Generation of BBB permeable, potent, effective and selective CSF1R inhibitors to prevent neuroinflammation
