Asset

  • No.

    149

  • Asset Title

    Novel Nanoparticle Composition Targeting Marginated Leukocytes

  • Organization

    University of Pennsylvania

  • Product Type

    Nanoparticle

  • Therapeutic Area

    Inflammatory disease

  • Development Stage

    Hit To Lead or Lead Optimization

  • Technical Summary

    Arrangement of protein in or on the nanoparticles via hydrophobic interactions, crosslinking and electrostatic interactions. 

    • Acute inflammatory diseases, including sepsis, pneumonia, and acute respiratory distress syndrome (ARDS), account for over 1.5 million hospitalizations and 300,000 deaths per year in the US. These diseases all share a common cellular player known as marginated leukocytes. 

    • Marginated leukocytes are white blood cells that accumulate in the blood vessels of inflamed organs and potentiate disease progression by releasing toxins and pro-inflammatory cytokines and induce clotting and further inflammation. Accumulation of marginated leukocytes can ultimately lead to organ dysfunction. 

    • Inventors developed a molecular label consisting of an IgG antibody bound to dibenzocyclooctyne (D20 tag). When attached to nanoparticles, the D20 tag almost exclusively localized to marginated leukocytes to alleviate disease symptoms in a small animal model of acute inflammatory injury. 

    • Using the D20 tag to target marginated leukocytes with imaging agents or drugs could better enable clinical diagnosis and treatment of acute inflammatory diseases. 

  • Patent

    WO2021/113519A1

  • Publication

    Supramolecular Arrangement of Protein in Nanoparticle Structures Predicts Nanoparticle Tropism for Neutrophils in Acute Lung
    Inflammation. Nat Nanotechnol. (2022)

  • Attachment

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